Mr. and Mrs. Little (Hugh Laurie and Geena Davis, respectively) want to adopt a brother for their only child, George (Jonathan Lipnicki). They get more than they bargained for at the orphanage, however, when they meet the precocious Stuart (voiced by Michael J. Fox) -- a mouse with an attitude. Stuart soon becomes a member of the Little family, but he may not be around long ... if family cat Snowbell (voice of Nathan Lane) can make a meal of him!